Furthermore, QTVR can easily be used in transforming newer, high-resolution clinical imaging data to produce standardized, interactive ''virtual reality learning objects'' (VRLOs Trelease and Rosset, 2008 Unfortunately, as computer multimedia and web technologies have continued to evolve, web browsers have begun to move away from supporting media software ''plug-ins,'' such as those needed for running QTVR objects and panoramas. QuickTime VR (QTVR) has been a popular multimedia software format for conveniently producing interactive, simulated 3D objects that can run ''stand-alone'' on personal computers (PCs) and embedded in web pages ( Trelease et al., 2000 Nieder et al., 2000Nieder et al.,, 2004). In legacy approaches to e-learning, computer-based three dimensional (3D) and virtual reality (VR) visualization and simulation methods have been used to allow interactive study of anatomical structures, relationships, and concepts, both within and outside of the confines of laboratories and lecture halls (Trelease, 1996(Trelease,, 1998. Four separate practical applications are presented for light and electron microscopy, dissectable preserved specimens, and explorable functional anatomy in magnetic resonance cinegrams. But what is really included in QuickTime VR and how can it be easily used to produce novel and innovative visualizations for education and research? This tutorial introduces the QuickTime multimedia environment, its QuickTime VR extensions, basic linear and non-linear digital video technologies, image acquisition, and other specialized QuickTime VR production methods. While its core functions might be most commonly employed for production and delivery of conventional video programs (e.g., lecture videos), additional QuickTime VR "virtual reality" features can be used to produce photorealistic, interactive "non-linear movies" of anatomical structures ranging in size from microscopic through gross anatomic. Continuing evolution of computer-based multimedia technologies has produced QuickTime, a multiplatform digital media standard that is supported by stand-alone commercial programs and World Wide Web browsers.
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